National Trends in the Incidence and Stage of Disease At Initial Presentation for Patients With Pancreatic Adenocarcinoma
Gautam K. Malhotra*1, Lynette M. Smith2, Quan P. Ly3, Aaron R. Sasson3, Chandrakanth Are3
1College of Medicine, University of Nebraska Medical Center, Omaha, NE; 2Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE; 3Division of Surgical Oncology, Department of Surgery, University of Nebraska Medical Center, Omaha, NE
Background:There is a paucity of data on trends in the incidence and stage of disease (SOD) at initial presentation for patients with pancreatic cancer (PC). The aims of the study were to analyze the national trends in the incidence and SOD at initial presentation for patients with PC as stratified by location. Methods:The Surveillance, Epidemiology, and End Results (SEER) database (SEER 17, 2000-2007) was used to identify patients with pancreatic cancer located in the head (C25.0), body (C25.1), or tail (C25.2). SEER*Stat 6.6.2 was used to calculate age-adjusted incidence data which is presented as number of new cases per 100,000. The SOD (localized, regional and distant) at initial presentation was analyzed to detect trends. Results:Overall, we found a modest increase in the incidence of pancreatic cancer for all locations from 7.5 in 2000 to 8.1 per 100,000 in 2007. This increase in the incidence was predominantly due to significant increases in the number of patients with lesions located in the body (0.86 to 1.2 cases per 100,000; 43% increase, p < 0.05) and tail (1.0 to 1.4 cases per 100,000; 36% increase, p < 0.05) of the pancreas. There were no significant changes in the incidence of lesions located in the head of the pancreas. We also noted a statistically significant increase in the incidence of patients with localized disease involving all locations (0.54 to 0.63 cases per 100,000; increase of 16%, p < 0.05). The increase in the incidence of localized disease was more pronounced for lesions located in the body (0.06 to 0.09 cases per 100,000; 39% increase, p < 0.05) and tail of the pancreas (0.06 to 0.12; 98% increase, p < 0.05).Conclusion:This study indicates that there is a modest increase in the overall incidence of pancreatic cancer which is largely due to notable increases in the incidence of lesions involving the body and tail of the pancreas. The data also demonstrated an increase in the incidence of localized disease at the time of initial presentation which was again more pronounced for lesions located in the body and tail.
Back to 2011 Program
