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INTRODUCTION: The pathophysiology of esophageal epiphrenic diverticula is still uncertain even though a concomitant motility disorder is found in the majority of patients in different series. High resolution manometry may allow detection of motor abnormalities in a higher number of patients with esophageal epiphrenic diverticula compared to conventional manometry. AIMS: This study aims to evaluate the high resolution manometry findings in patients with esophageal epiphrenic diverticula.METHODS: Nine individuals (mean age 63± 10 years, 4 females) with esophageal epiphrenic diverticula were studied. All patients underwent an upper digestive endoscopy and barium esophagram. A single diverticulum was observed in 8 patients and multiple diverticula in 1. All patients underwent a high resolution manometry. Pressure and relaxation of the upper and lower sphincters were recorded. Esophageal body function was measured at 3 and 7 cm above the upper border of the LES. Visual analysis of color pressure plots for identification of segmental abnormalities was performed by 2 researchers experienced in HRM. RESULTS: Upper esophageal sphincter was normal in all patients. Esophageal body was abnormal in 8 patients, lower esophageal sphincter was abnormal in 4 patients. Named esophageal motility disorders were found in 7 patients: achalasia in 6, diffuse esophageal spasm in 1 . In 1 patient, a segmental hypercontractile zone was noticed with pressure of 196mmHg.CONCLUSION: High resolution manometry demonstrated motor abnormalities in all patients with esophageal epiphrenic diverticula.