Comorbidities Remission After Roux-en-Y Gastric Bypass for Morbid Obesity Is Sustained in a Long-Term Follow-up
Rafael M. Laurino Neto1, Fernando a. Herbella*1, Renato M. Tauil1, Fabricio S. Silva1, Marco G. Patti2
1Department of Surgery, Federal University of Sao Paulo, Sao Paulo, Brazil; 2Department of Surgery, University of Chicago, Chicago, IL
INTRODUCTION: Roux-en-Y gastric bypass (RYGB) is considered an effective therapy for weight loss although weight regain may be observed in a long-term follow-up. Obesity-related comorbities are also well treated by RYGB due to weight loss and intestinal hormone changes. Few studies reported long-term status of comorbities especially if weight regain is present.AIMS: This study aims to analyze: (1) the resolution of obesity-related comorbities after RYGB in a long-term follow-up and (2) its relationship to weight regain.METHODS: 143 patients (mean age 41, 18 male) were followed-up after RYGB for morbid obesity for at least 5 years (mean follow-up 90, range 60-155 months). Mean body mass index before operation was 52 (range 39-82) Kg/m2. Diabetes, cardiopaty, arterial hypertension, dyslipidemia, sleep apnea, arthropathy, and infertility were present in 26(18%), 13(9%), 89(62%), 18(12,5%), 85(60%), 88(61,5%), 7(8%)patients, respectively. RESULTS: Mean body mass index at last follow-up was 33 (range 19-47) Kg/m2. Comorbidities status is depicted in table 1. Comorbidities resolution was not related to the % of weight loss for cardiopathy (p=0.7), hypertension (p=0.3), dyslipidemia (p=1), sleep apnea (p=0.1), and infertility (p=0.2) but it was related to arthropathy (p<0.001).CONCLUSION: Our results show that comorbidities remission after RYGB is sustained in the majority of patients in a long-term follow-up. Weight regain is linked to worse results for arthropathy.
| Diabetes | Cardiopathy | Hypertension | Dyslipidemia | Sleep apnea | Arthropathy | Infertility | |
| resolved | 77% | 31% | 57% | 72% | 50% | 19% | 28% |
| improved | 23% | 46% | 38% | 22% | 46% | 52% | 28% |
| unchanged | 0 | 15% | 55% | 0% | 2% | 25% | 43% |
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