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Laparoscopic pancreaticoduodenectomy is technically challenging but gaining interest as international experience grows. We present a case of a 25 year old female who was diagnosed with a psuedopapillary tumor in the head of the pancreas abutting the SMV. Our video will demonstrate our technique for a totally laparoscopic pancreaticoduodenectomy with vascular isolation of the SMV via caudal-cranial approach. We have applied this technique to both benign and malignant lesions of the pancreas and ampulla with excellent results.