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Introduction: Although the technique and safety of laparoscopic liver resection have been well described in the literature, there is a paucity of reports regarding oncologic results. The aim of this study is to assess the oncologic outcome following laparoscopic resection of malignant liver tumors. Methods and Procedures: Fourty-one patients underwent laparoscopic resection of malignant liver tumors between April 2006 and September 2009. Data were collected prospectively with IRB approval. Peri-operative parameters, as well as overall and disease-free survival were analyzed. The patients were followed quarterly with tumor markers and chest-abdomen-pelvis CT scans for the first 2 years and then biannually. Statistical analysis was performed using Kaplan Meier survival tests. All data are expressed mean ± SEM. Results: There were 24 males and 17 women. Mean age was 64.1 ± 7.3 years. Pathology included colorectal liver metastasis (n=24), hepatocellular cancer (n=12), and sarcoma, GIST, renal cell cancer, breast cancer and neuroendocrine cancer metastasis in 1 patient each. Twenty-two patients underwent wedge resection or segmentectomy, 15 patients bi-segmentectomy, 2 patients left hepatectomy, 1 patient right hepatectomy + segment 4B resection, and 1 patient right hepatectomy. There was one conversion to open due to bleeding (2.5%). Mean tumor size was 3.2 ± 0.3 cm. Mean operative time was 254.6 ± 86.3 minutes. Mean estimated blood loss and length of hospital stay was 210.7 ± 80.2 ml and 3.6 ± 1.2 days respectively. The average surgical margin was 10.8 ± 3.1 mm. There was no mortality. Complications were seen in 16% of the cases. The patients were followed-up for a mean of 17.2 ± 1.6 months. No port-site metastasis or local recurrence detected during the follow-up. Three-year Kaplan Meier estimated overall and disease-free survival rates were 72% and 55%, respectively. In follow up, 4 patients developed new liver and 3 patients extrahepatic recurrence. The latter 3 patients died due to extrahepatic disease progression. Conclusion: The absence of local and port-site metastases in our study proves that the laparoscopic approach follows surgical oncologic principles. The short-term overall and disease-free survival are favorable. Due to better patient recovery, we believe that it should be the procedure of choice in selected patients.