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Introduction. Hepatic surgery has evolved significantly in the past decade. In an attempt to decrease intraoperative complications ie, bleeding and postoperative complications, various techniques have been applied. These have been decreasing intraoperative central venous pressure to utilizing staplers and other energy devices such as Radiofrequency. Although MW use has been reported for hepatic cancer ablations, it remains unknown if it is efficacious for precoagulation prior to transaction. We report a novel approach, at a single institution, for liver precoagulation with MW technology.Methods: Peritoneal cavity was accessed and inflow and outflow control was secured. Glisson’s capsule was then incised using electrocautery. Two antennae, 2cm apart, were connected to 915MHz generator at 10W and were inserted 5cm deep into liver parenchyma. The antennas were advanced into the liver parenchyma at a 130 degree angle, 2 cm apart. Once the liver parenchyma was firm and had changed its color to grey, the antennae were progressively advanced along the line of transaction at approximately 20 second intervals. The liver parenchyma was divided with electrocautery following precoagulation with the MW antennae. Intra and post operative data were analyzed. First order divisions(left,right or extended hepatectomy) were grouped as major resections. All other resections were grouped as minor resections. Results: Thirty five patients(24 men) with a median age of 60 yrs underwent liver resections. Diseases treated were colorectal metastasis(n=9), hepatic adenoma(n=3), gallbladder cancer(n=3), hepatocellular carcinoma(n=4), neuroendocrine tumor(n=2), cholangiocarcinoima(n=5), hemangioma(n=2), focal nodular hyperplasia(n=2), metastatic GIST(n=1), hydatid cyst(n=1), hepatoid carcinoma(n=1) and hepatolithiasis(n=1) suspected metastatic breast cancer(n=1). Resections done were right hepatectomy(n=19), segmental resection(n=5), left hepatectomy (n=4), extended right hepatectomy(n=4), segment IVB and segment V resections during radical cholecystectomy(n=2), left lateral sectionectomy(n=1). Median operative time for major resection was 188 and 251 mins for minor. There was one postoperative mortality due to respiratory failure. Bile leak needing stenting occurred in 1 patient. Median blood loss for major resection was 500 ml and 265 ml for minor. Intraoperative transfusion was required in 9 major and 1 minor resections. Other complications were ileus in 4, DVT in 2, intrabdominal abscess in 1 and cardiac events in 2 patients.Conclusion: Liver precoagulation with MW technology is a novel and efficient technique with minimal morbidity and mortality for liver transection.