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Purpose: This study was to assess the feasibility and safety of transvaginal specimen extraction for laparoscopic colectomy.Methods: Twenty consecutive patients with benign huge colon or rectum polyp were indicated for surgery of laparoscopic colectomy. A full laparoscopic colectomy was successfully performed for all cases. The specimen was extracted via a tranvaginal route.Results: The mean age of the patients was 68 years old and mean body mass index was 25.5 kg/m2. The average size of tumor was 4.5 cm. The mean operative time was 165 minutes while the average estimated blood loss was 50 ml. The average hospital stay was 8 days. The mean VAS was 5. Postoperative complications include ileus (n=1) and urinary tract infection (n=1). There was no vaginal wound infection nor surgical mortality.Conclusions: This technique of transvaginal sepcime extraction for laparoscopic colectomy effectively preserved the benefits of laparoscopic surgery without abdominal wound-related complications.