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Relation Between Helicobacter Pylori Infection and Gastric Cancer in a Single Institution
Eduardo E. Montalvo-Jave*1,4, Oswaldo Cardenas1, Sergio R. Sobrino-Cossio3, Rolando Hernandez-MuñOz2
1Department of Surgery, Hospital General de Mexico, Mexico City, Mexico; 2Biología Celular, Instituto de Fisiología Celular. UNAM, Mexico City, Mexico; 3Endoscopia Gastrointestinal, Instituto Nacional de Cancelogía, Mexico City, Mexico; 4Department of Surgery, Facultad de Medicina. UNAM, Mexico City, Mexico
Introduction. Gastric cancer (GC) is the 14th cause of death in Mexico; alcohol, tobacco, diet, and, lately, infection by Helicobacter pylori (Hp) include some of the associated risk factors. We studied the prevalence of Hp infection and gastric cancer at a single institution. Materials and Methods. All histopathological reports of stomach biopsies (endoscopic and surgical) received at the institution's Pathology Service between January 1, 1995 and April 30, 2002 were included in the study. Age, gender, Hp infection detected by Hematoxylin-eosin (HE), Giemsa, and Warthin-Starry stains, and type and location of the gastric malignancy were the variables analyzed. We calculated the frequency, prevalence, percentage, and odds ratio to establish the relationship between Hp infection and Gastric adenocarcinoma (GA). Results: A total of 8,040 gastric biopsies were studied; of these, 3,934 were positive for Hp infection and 529 were diagnosed with GA. Only 70 GA biopsies were positive for Hp infection (13%). Mean age of patients was 57.3 years and male:female ratio was 1:1. There were no statistical differences between intestinal and diffuse subtypes. Conclusions: We found a relation of 13% between CG and Hp infection in an open Mexican population at the institution, a finding that is similar to those reported in series from China, Japan, Costa Rica, and other countries.
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