PIVOTAL PROGNOSTIC AND DIAGNOSTIC ROLE OF THE LONG NON-CODING RNA COLON CANCER-ASSOCIATED TRANSCRIPT 1 EXPRESSION IN HUMAN CANCER
Ni Wang*, Lin Miao
The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China
Long non-coding RNAs (lncRNAs) have been classically defined as regulatory RNA members greater than 200 nucleotides in length, without detectable open reading frame (ORF) to encode protein. Increasingly, studies have shown that lncRNAs play critical roles in multiple cancers. Colon cancer-associated transcript 1 (CCAT1), a new star among cancer-related lncRNA, is significantly overexpressed in a number of malignancies. Functionally, as an oncogenic lncRNA, CCAT1 is involved in proliferation, migration, cell cycle progression, apoptosis, chemoresistance and other biological processes of cancer cells through complex regulation mechanisms in the cytoplasm or nucleus. In clinical applications, CCAT1 is also in positive relationship with histological differentiation, tumour node metastasis (TNM) stage, vascular invasion, overall survival (OS) and relapse-free survival (RFS), which reveals its important role as a diagnostic and prognostic marker in cancer. The present review summarizes the current research progress of the oncogenic potential and clinical utilities of CCAT1 in various human cancers.
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