FAMILY HISTORY FOR GASTROESOPHAGEAL REFLUX DISEASE (GERD) DOES NOT AFFECT POST-OPERATIVE OUTCOMES FOLLOWING ANTIREFLUX SURGERY
Rehma Shabbir*, Marc A. Ward, Steven G. Leeds
Surgery, Baylor University Medical Center, Dallas, TX
Introduction: Family history has a significant impact on a number of disease processes, but its impact on patients undergoing antireflux surgery (ARS) for gastroesophageal reflux disease (GERD) is unknown. The aims of this study were 1) to determine if patients with a positive family history are more likely to undergo ARS and 2) does family history affect post-operative outcomes following ARS?
Methods: Patients who were evaluated for GERD between September 2014 and October 2017 were prospectively followed in an institutional review board-approved database. All patients with objectively confirmed GERD (DeMeester score >14.7, grade C or D esophagitis on endoscopy, or the presence of a paraesophageal hernia) were included. Objectively confirmed GERD patients without a complete family history for GERD or ARS were excluded. Statistical significance was evaluated with t-tests using SPSS software.
Results: There were 309 patients that met study criteria. Ten patients were eliminated because of an unknown family history resulting in a cohort of 299 patients. 172 patients (58%) reported a positive family history for GERD on initial evaluation. 53% of patients (91/172) with a positive family history (+FH) underwent ARS compared to 46% (59/127) patients with a negative family history (-FH). No differences in GERD HRQL scores were seen between the two groups preoperatively or post-operatively at 6 months and 1 year (Table 1). Mean GERD HRQL scores decreased from 65 to 12 at 1 year following ARS in the + FH group and from 66 to 10 in the -FH group. These changes in GERD HRQL scores at 1 year compared to values prior to surgery were significant in both groups (p <0.05).
Conclusions: Patients with a positive family history for GERD are more likely to undergo antireflux surgery. Outcomes following antireflux surgery are not affected by the presence of a positive family history for GERD.
Table 1
| +FH GERD | -FH GERD | p value | |
| Preoperative GERD HRQL | 65 | 66 | (p > 0.05) |
| 6 month Post-op GERD HRQL | 21 | 15 | (p > 0.05) |
| 1 year Post-op GERD HRQL | 12 | 10 | (p > 0.05) |
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