Background: Radical surgery for gastric stromal tumors (GIST) entails a free-margin gastric resection without the requirement for associated lymph-node resection. For this reason, minimally invasive surgery represents an excellent option for the management of many of these tumors. Conventional laparoscopy with wedge resection is an option for anterior wall tumors, however, endoluminal growing lesions, especially when located at the posterior gastric wall close to the cardia or at the gastric fundus are troublesome for a standard laparoscopic approach due to technical difficulties. In this setting, endogastric laparoscopic resection may offer an excellent surgical field for resection of these tumors. Patients and Methods: Between January 2004 and June 2005, eight patients with GIST were managed by laparoscopic resection and were retrospectively reviewed. Results: Five patients were managed by laparoscopic endogastric resection and three by laparoscopic wedge resection. The mean operative time for these procedures was 182.1 ± 10.2 min. In all three patients managed by wedge resection a linear stapler was used to remove the tumor, for the remaining 5 managed by endogastric resection, the tumor was removed with a harmonic scalple. There was no conversion to open surgery. All 8 resected specimens had free margins. None of the patients presented any significant perioperative morbidity and there was no mortality. Conclusions: Laparoscopic surgery for both wedge and endogastric resections are safe and adequate radical treatment options for GIST with low morbidity and mortality rates. Further study is needed to evaluate these results.