Traditionally gastric stromal tumors necessitated open wedge resection. We reported a series of laparoscopic wedge resection for gastric stromal tumors. Patients & methods: Sixty-seven patients with submucosal gastric tumours diagnosed by upper endoscopy or incidentally diagnosed by laparoscopy were recruited. Pre-operative imaging with CT scan and endoscopic ultrasound were performed for clinically stable patients. Patients with actively bleeding lesions underwent emergency operations. Patients with lesions located at cardia and pylorus, exceptionally large lesions, and those lesions with imaging revealed adjacent viscera invasions or metastasis were excluded. Diagnostic laparoscopy and laparoscopic ultrasound were performed prior to tumors resections. Extragastric closed technique was employed for mobile tumors with adequate surrounding normal gastric wall. Transgastric approach via gastrototomy was employed whenever extragastric technique was not feasible and precise lesion localization and resection was required. Operative time, time to resumption of full diet, analgesic requirement, post-operative stay, morbidity and mortality were analysed prospectively. Results: From June 1995 to October 2005, perioperative data of 67 patients, aged 28-84 (mean 64.5) with gastric stromal tumors underwent laparoscopic wedge resection was prospectively collected for analysis. There were 35 men and 32 women; twenty of them had significant co-morbidities and belonged to ASA classes III or IV. The lesions were located at gastric body (18), fundus (24), lesser curve (15), greater curve (7), and closed to esophageal-gastric junction (3). Extragastric closed techniques were employed for 16 tumors, and 51 lesions were extirpated via gastrotomy. Average operative time was 82.3 (35-180) minutes. Twelve patients necessitated conversions to open for esophago-gastric junction lesions (3), broad-based and retroperitoneal adhesions at the fundus (3), high lesser curve lesions (4), and technical difficulty (2). Patients required 2 doses (mean) of post-operative pethidine injection and 5 days (median) to resume full diet. The median post-operative stay was 6 days. Two ASA IV patients developed post-operative stroke. One patient with posterior fundal lesion removed was complicated by reactionary hemorrhage and radiological evidence of leakage, which was managed conservatively. Another patient had diffuse peritoneal metastasis 30 months after the procedure. In conclusion: Laparoscopic wedge resection of gastric stromal tumors is safe and feasible and associated with satisfactory post-operative outcomes.