[Aims] Standard treatment of proximal gastric cancer is total gastrectomy with D2 lymph node dissection. But, role of splenectomy in the surgical management of proximal gastric cancer is still controversial. Aim of this study is to evaluate the effect of simultaneous splenectomy on the survival of patients who underwent curative total gastrectomy for proximal gastric cancer. [Methods] Ninety-two patients who underwent curative total gastrectomy for gastric cancer were included. Patient’s characteristics, pathologic features, TNM stages and prognosis were compared between splenectomy (n=63) and preserving group(n=29). [Results] There was no difference in age, sex ratio, tumor location between two groups. In terms of gross tumor morphology, splenectomy group had more advanced diseases significantly (p<0.05). There was no difference in tumor differentiation and diameter (6.7 Vs. 5.4 cm) between two groups. Proximal(3.3 Vs. 3.6 cm) and distal(9.3 Vs. 9.3 cm) resection margin, number of retrieved lymph nodes(35.5 Vs. 33.9), number of metastatic lymph node(9.5 Vs. 7.8) also showed no differences. Regarding TNM stages, there were more advanced stage significantly in splenectomy group. Disease-free survival showed no significant difference in TNM stage I&II (82.4% Vs. 85.7%) and in TNM stage III & IV (42.3% Vs. 49.1%) between splenectomy and preserving group. Multivariate-analysis with Cox-hazard regression model showed that only TNM stage was independent prognostic factor(p<0.05). Splenectomy itself had no influence on patient’s survival. [Conclusions] Splenectomy was performed more frequently in advanced gastric cancer and simultaneous splenectomy had no effect on the survival of patnents who underwent curative gastrectomy for proximal gastric cancer. Randomized prospective clinical trial using more precise criteria to indicate the need for splenectomy are need.