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2006 Abstracts: Clinical significance of SUMO-1 in esophageal squamous cell carcinoma
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Clinical significance of SUMO-1 in esophageal squamous cell carcinoma
Yoshio Ishibashi1, Yutaka Suzuki1, Hideyuki Kashiwagi1, Nobuyoshi Hanyu1, Koji Nakada1, Nobuo Omura1, Naruo Kawasaki1, Koji Takada2, Mitsuyoshi Urashima3, Katsuhiko Yanaga1; 1Surgery, Jikei University Shool of Medicine, Tokyo, Japan; 2Biochemistry, Jikei University School of Medicine, Tokyo, Japan; 3Division of Clinical Research and Development, Jikei University School of Medicine, Tokyo, Japan

PURPOSE: SUMO-1 (small ubiquitin-related modifier-1) is a novel ubiquitin-like protein that is conjugated like ubiquitin, by a set of enzymes to cellular regulatory proteins including oncogenes and tumor suppressor genes. In this study, we aimed to investigate the significance of SUMO-1 expressions in cancerous esophageal lesions as a prognostic factor. METHOD: Tissue samples from 101 patients with esophageal squamous cell carcinoma were stained with anti-SUMO-1 antibody for immunohistochemical analysis. Using oligonucleotide microarrays, we analysed total RNA expression levels of ubiquitin-related genes in paired cancerous and normal tissue operative specimens in 12 patients. Immunoblot analysis of the paired cancerous and normal tissue samples were examined using an anti-SUMO-1 antibody. RESULT: SUMO-1 overexpression in cancerous tissues was related to lymphatic vessel invasion (p<0.001). Hierarchical clustering analysis using gene expression ratios (cancer/normal) divided the 12 patients into two groups. The expression of SUMO-1 was up-regulated in the poor prognostic cluster. Various bands of proteins conjugated with SUMO-1 were present in both cancerous and normal tissues. In esophageal squamous cell carcinoma, some peculiar bands which were absent in the normal tissue were recognized. CONCLUSION: In esophageal squamous cell carcinoma, overexpression of SUMO-1 correlated with lymphatic vessel invasion and a poor prognosis. SUMO-1 conjugation may important in the course of tumorigenesis.


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