Ambulatory wireless 48-hour esophageal pH monitoring (Bravo Medtronic, Shoreview, MN) has been shown to be more sensitive in detecting abnormal esophageal acid exposure compared with trans-nasal 24-hour pH probes. However, accurate interpretation of the wireless monitoring data is paramount when contemplating surgical intervention for those with gastroesophageal reflux disease. The aim of this study is to evaluate the incidence of false positive interpretations of this wireless data secondary to premature transit of the Bravo probe into the stomach and subsequently into the duodenum prior to the completion of the 48-hour study period. We reviewed 100 consecutive Bravo pH studies at our University Esophageal Motility. There were 58 women and 42 men included in our evaluation. Premature transit of the Bravo probe into the stomach and subsequently into the small bowel was defined by a prolonged gastric pH phase with either evidence of alkalinization and no further reflux episodes or loss of communication with the Bravo capsule prior to the end of the 48 hour data collection period. Of the 100 patients reviewed, 11% manifested evidence of early passage of the Bravo probe resulting in misinterpreting the data as abnormal esophageal acid exposure. The mean time of inaccurate data recording after transit of the Bravo capsule was 18 hours and 42 minutes. The mean length of time that the probe was retained in the stomach prior to duodenal passage was 4 hours. If the aforementioned false data was included in the final interpretation of the study it yielded a mean DeMeester score of 44.25 with a mean total time of pH<4 of 14.7% per case. Exclusion of the prolonged gastric phase from the final interpretation of each case resulted in a statistically significant reduction in the mean total time the pH < 4 (4.33% vs. 14.7%, p < 0.05) and the mean DeMeester score (12.81 vs. 44.25 p < 0.05). The mean time from the initiation of esophageal pH data collection to passage of the Bravo probe into the stomach was 15 hours and 22 minutes. Falsely elevated esophageal acid exposure can be recorded by the computer as a result of early passage of the Bravo probe into the stomach. This observation mandates meticulous inspection of the pH tracing by the interpreting physician throughout the entirety of a 48-hour study in order to identify premature transit of the capsule. Tracings that show prolonged acid exposure or loss of communication with the Bravo probe should be screened for its possible early dislodgement and premature advancement into the stomach.