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2007 Program and Abstracts | 2007 Posters
Midkine As a Prognostic Marker for Gastrointestinal Stromal Tumors
Kai Bachmann*1,4, Jussuf T. Kaifi1, Henning C. Fiegel2, Kuniaki Aridome4, Paulus G. Schurr1, Uta Reichelt3, Keiko Ichihara-Tanaka5, Takashi Muramatsu5, Dietrich Kluth2, Tim Strate1, Jakob R. Izbicki1
1Department of General, Visceral and Thoracic surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany; 2Department of Pediatric Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany; 3Institute for Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany; 4Department of Surgery, Kagoshima University, Kagoshima, Japan; 5Department of Health Science, Aichi Gakuin University, Aichi, Japan

Background: Midkine (MK), a heparin-binding growth factor, has an important role in cancer progression in different tumor types. The aim of this study was to determine MK expression in gastrointestinal stromal tumors (GISTs) that derive from the institial neuronal cells of Cajal in myenteric plexus of the intestine.
Materials and Methods: 57 patients with GIST that were surgically treated between 1985 and 2004 were chosen retrospectively and a clinical follow-up was performed.
Results: MK was detected in 31 (55%) of 57 surgically resected GISTs by immunohistochemistry. A significant worse outcome of MK-positive patients was found (p<0.05; log rank test). Multivariate Cox regression analysis showed an independent prognostic impact (relative risk for overall survival 3.64; p<0.05). Interestingly, MK expression was significantly associated with mitotic rate (p<0.05; Chi-squared test), but not with tumor size (p=0.97).
Conclusion: Taken together, MK is an independent prognostic marker for surgically treated GIST patients. Since it can be detected in peripheral blood, future studies might focus on the usefulness of MK as a peripheral tumor marker in GIST patients.


2007 Program and Abstracts | 2007 Posters
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