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1998 Abstract: LIVER RESECTION FOR NONCOLORECTAL NONNEURO-ENDOCRINE HEPATIC METASTASES. T. D.Sielaff, B. Langer, T. Van der Meer, B.R. Taylor, P.D. Greig, S. Gallinger, A.W. Hemming. Department of Surgery, University of Toronto. Toronto, Ontario, Canada. 135

Abstracts
1998 Digestive Disease Week

#1039

LIVER RESECTION FOR NONCOLORECTAL NONNEURO-ENDOCRINE HEPATIC METASTASES. T. D.Sielaff, B. Langer, T. Van der Meer, B.R. Taylor, P.D. Greig, S. Gallinger, A.W. Hemming. Department of Surgery, University of Toronto. Toronto, Ontario, Canada.

The indications for the resection of noncolorectal/nonneuroendocrine hepatic metastases (NCNNE) have evolved as the safety of hepatic resection has increased. The prognostic features of NCNNE treated surgically were reviewed in order to better define the indications for resection. Methods: A retrospective review of patients undergoing liver resection for NCNNE between 1978 and 1997. Results: Thirty patients were identified. The mean age was 57 years with a median follow up of 18 months. Primary tumor sites included GI adenocarcinoma (bowel n=3, unknown n=2, pancreatic n=2, esophageal n=1), and other (renal cell n=5, testicular n=1, ovarian n=1, sarcoma n=6, adrenal n=3, melanoma n=3, thyroid n=2, and breast n=1). All patients were operated upon for cure. Synchronous metastases were treated in 9 patients. There was no operative mortality. Overall survival is shown in Figure 1. Survival was better in patients with non-GI origin metastases (Figure 2, p=0.04). Long term survivors were seen only in patients with non GI origin metastases. Neither the extent of resection (segmental n=11, lobe n=14, extended n=5) nor the presence of synchronous metastases was predictive of outcome.

Conclusions: Patients with NCNNE hepatic metastases can undergo liver resection with an expectation of prolonged survival. However, patients with GI tract origin non-colorectal adenocarcinoma metastatic to the liver are unlikely to demonstrate extended survival.

Copyright 1996 - 1998, SSAT, Inc. Revised 29 June 1998.



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