VASCULAR RESECTION AND RECONSTRUCTION IN HILAR CHOLANGIOCARCINOMA
Wong-Hoi She*, Tan To Cheung, Ka Wing Ma, Simon H.Y. Tsang, Wing Chiu Dai, Albert Chan, Chung Mau Lo
Surgery, The University of Hong Kong, Hong Kong, Hong Kong
Introduction: The aggressive approach of vascular resection plus reconstruction in curative resection of hilar cholangiocarcinoma (HC) remains controversial. This retrospective study investigated its short- and long-term outcomes.
Methods: Data of HC patients from 1989 to 2016 were reviewed. Operated patients were divided into two groups (with and without vascular resection) and compared in terms of perioperative results. Patients who had unresectable HC were also compared with patients who had been operated.
Results: Ninety patients underwent curative HC resection. They were divided into Group A (without aggressive approach, n=68) and Group B (with aggressive approach, n=22). The groups were comparable in all parameters including rates of overall and major complication and in-hospital, 30-day and 90-day mortality except that Group B had more patients with more advanced disease (p=0.008), more patients with tumor invasion of the vasculature (40.9% vs. 7.4%, p=0.001), and fewer patients with blood transfusion (27.3% vs 52.9%, p=0.036). The groups had similar disease-free survival (Group A: median, 17.9 months, 5-year, 27.4%; Group B: median, 11.7 months, 5-year, 14.3%; p=0.427) and overall survival (Group A: median, 22.0 months, 5-year, 26.5%; Group B: median, 26.5 months, 5-year, 14.7%; p=0.90). Two hundred patients with unresectable HC were compared with patients who had received operation and found to have worse survival outcomes (p<0.001).
Conclusions: Vascular resection plus reconstruction in HC resection was feasible and safe and might improve the long-term survival of patients with advanced HC. This aggressive approach should be adopted if the expertise is available and the patient's condition allows.
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