PREOPERATIVE HYPERCOAGULABLE THROMBOELASTOGRAPHY PROFILES ARE ASSOCIATED WITH POST-OPERATIVE VENOUS THROMBOEMBOLISM IN INFLAMMATORY BOWEL DISEASE PATIENTS
Prashansha Vaidya*, Chun Hin Angus Lee, Amy Lightner, Tracy L. Hull, Scott Steele, Stefan D. Holubar
Cleveland Clinic Colorectal Surgery, Cleveland, OH
Background
We previously reported our pilot experience using thromboelastography (TEG) to assess hypercoagulability in 19 inflammatory bowel disease (IBD) surgical patients. We now report our expanded experience in 55 patients. Our hypothesis is that a hypercoagulable TEG (HyperTEG) profile is associated with post-operative venous thromboembolism (VTE) after surgery for IBD.
Methods
This was a single institution IRB-approved study from June 2018 - July 2019. Preoperative TEGs were obtained as part of routine preoperative labs in consecutive adult patients with either Crohn’s disease (CD) or ulcerative colitis (UC) who underwent major abdominopelvic surgery. Patients were stratified into two groups based on their TEG profiles: Normal vs. HyperTEG. HyperTEG was defined as at least 2 of the 3 abnormal for clotting TEG parameters: 1) low R-value, 2) high degree angle, 3) high maximum amplitude (MA). Clinical data was collected by retrospective chart review. The primary endpoint was VTE. Potential differences between groups were assessed with nonparametric univariate analysis.
Results
A total of 55 IBD patients were included, and 37% (n=20) patients had a HyperTEG profile. The median age at the time of surgery was 40 (21 – 84); 57% (n=31) were women and most patients had CD 67% (n=37). Overall 47% (n=26) patients were receiving oral steroids and 51% had received a biologic within 90 days (15 patients were receiving both), while 12 (22%) of patients were hospitalized pre-operatively. One patient (1.8%) had a coagulation index of -21 indicative of a bleeding disorder and was referred to hematology and was found to have factor V Leiden deficiency. There were no statistically significant differences between baseline or perioperative characteristics between the Normal and HyperTEG patients as shown in Table 1. The VTE rate was 0 in the Normal group and 15% in the HyperTEG group (p=0.04). The overall median length of stay was 6 days (1, 35). The 30-days post-operative readmission rate was 20% (n=11); none required return to the operating room, and VTE 5.5% (n=3). Table 2 shows the TEG parameters in non-VTE and VTE patients. All three (100%) VTE patients had a high degree angle (p=0.02) and high coagulation index (p=0.01) while 2 (67%) patients had a low R-value (p=0.13) and high MA (p=0.13). In this series, a preoperative HyperTEG, compared to a preoperative Normal TEG, was associated with the occurrence of post-operative VTE (p=0.04).
Conclusion
We observed that over one third of IBD patients have a hypercoagulable profile preoperatively, with an observed 15% VTE rate, despite prophylaxis with enoxaparin. Our finding suggests that an abnormal TEG profile is associated with VTE occurrence after surgery for IBD; it also suggests that stronger prophylaxis, or anticoagulation, may be indicated in these high-risk patients.
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