Back to 2017 Posters

---

LIVER RESECTION INDUCES ACUTE INTESTINAL BARRIER DYSFUNCTION IGFBP-1 AS A NOVEL BIOMARKER OF INTESTINAL INJURY
Marcel C C. Machado^*1,2, Hermes Barbeiro³, Heraldo P. Souza⁴, Fabiano Pinheiro⁵, Marcel Autran Machado^6
1Emergencia , University of sao paulo, sao Paulo, Brazil; ²Surgery, Hospital Sirio Libanes, Sao Paulo, Brazil; ³emergencia , university of sao paulo, Sao Paulo, Brazil; ⁴emergencia , University of Sao Paulo, Sao Paulo, Brazil; ⁵Emergencia , University of sao Paulo, Sao Paulo, Brazil; ⁶Surgery, Hospital sirio Libanes , Sao Paulo, Brazil

Introduction/Background Disruption of the intestinal barrier and bacterial translocation are common findings, when intestinal blood flow is compromised. Total or intermittent Pringle maneuvers and reduction of central venous pressure, have been used to minimize blood loss during liver resection. During Pringle maneuver, reduction of intestinal perfusion results in intestinal barrier dysfunction and endotoxemia . In the same direction, we hypothesized that reduction of central venous pressure during liver resection followed by reduction of arterial pressure would also reduce intestinal blood flow and damage the intestinal barrier Aims: The aim of this study was to investigate if liver resection even without Pringle maneuver induces intestinal damage
. Methods Intestinal fatty-acid binding protein (iFAPB) an accept marker of intestinal barrier damage and insulin-like growth factor binding proteins (IGFBPs) important physiologic regulators of the interaction of insulin-like growth factors (IGFs) with their receptors within the gastrointestinal tract and liver were determined in the plasma of 18 patients submitted to liver resection without Pringle maneuver. Results: We found a significant increase in plasma levels of IFABP IL-6 and IGFBP-1 8h after the start of the surgeries (fig 1,2). By the other hand, IGFBP-3, IGFBP-4, IGFBP-6 and IGFBP-7 plasma levels decreased after the surgical procedure Conclusion We conclude that liver resection is associated with significant intestinal barrier injury, even if Pringle maneuver is not performed. We propose, moreover, insulin-like growth factor binding protein-1 (IGFBP-1) as a novel biomarker of intestinal damage in such situations.
...

---

Back to 2017 Posters