SSAT - CLINICOPATHOLOGIC AND SURVIVAL DIFFERENCES IN YOUNGER PATIENTS WITH PANCREATIC DUCTAL ADENOCARCINOMA: A PROPENSITY SCORE-MATCHED COMPARATIVE ANALYSIS

Back to 2017 Posters

CLINICOPATHOLOGIC AND SURVIVAL DIFFERENCES IN YOUNGER PATIENTS WITH PANCREATIC DUCTAL ADENOCARCINOMA: A PROPENSITY SCORE-MATCHED COMPARATIVE ANALYSIS
Jae Seung Kang^*, Jin-Young Jang, Wooil Kwon, Youngmin Han, Sun-Whe Kim
Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea (the Republic of)

Background & purpose: Cancers in younger adults are generally thought to be more aggressive and to be diagnosed at more advanced stages, leading to unfavorable prognoses. Early-onset pancreatic cancer (EOPC) is not optimally characterized because of its extremely low incidence. We investigated clinicopathologic differences between younger or older patients with pancreatic cancer, and compared their outcomes.
Methods: We enrolled 814 consecutive patients who were diagnosed with pancreatic cancers and admitted to our surgical department between January 2000 and December 2014. Among those 699 (85.9 %) patients with pancreatic ductal adenocarcinoma (PAD), we compared demographics and clinical outcomes in patients who were younger and older than 45 years at diagnosis. We estimated 1:2 case propensity score matching (PSM) by a logistic regression model based on patients’ sex, ASA scores and postoperative AJCC stages.
Results: Among all 699 PAD patients, 5-year overall survival (OS) was 18.5%; median survival was 20 months. At diagnosis 34 patients (4.5%) were younger than 45 years. After PSM, the younger and older groups did not significantly differ by tested variables. Median survival periods were younger group: 17 months, older group: 15 months. Some 411 patients (63.1%) suffered postoperative recurrence, but did not significantly differ by age for overall (76.5 vs. 62.4%, P=0.104), local (14.7 vs. 18.5%, P=0.658) or systemic recurrence (70.6 vs. 54.4%, P=0.077), nor for disease-free survival (DFS; 8.9 vs. 17.4%, P=0.727).
Conclusion: Five-year OS, DFS, and recurrence patterns did not significantly differ between the EOPC and older pancreatic cancer groups. However, due to low incidence and resulting statistical power, further investigation is needed.

Back to 2017 Posters