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Sarcopenia Is Significantly Associated With Pancreatic Exocrine Insufficiency in the Patients With Pancreatic Disease
Ryuta Shintakuya*, Kenichiro Uemura, Yoshiaki Murakami, Naru Kondo, Naoya Nakagawa, Kazuhide Urabe, Hiroki Ohge, Taijiro Sueda
Surgery, Hiroshima University, Hiroshima, Japan
Objective: To determine whether body composition, including skeletal muscle (SM), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), intramuscular adipose tissue content (IMAC), and serum nutritional markers are associated with pancreatic exocrine function in patients with pancreatic disease.
Methods: Data were collected prospectively on 132 patients with pancreatic disease. SM, SAT, VAT and IMAC were assessed by computed tomography. Serum cholesterol, peripheral blood lymphocyte count, and serum albumin were measured as nutritional markers. Patients underwent a 13C-labeled mixed triglyceride breath test to measure pancreatic exocrine function. Patients were stratified by quartiles according to each body component, and for each component the lowest group was defined in the categorical analysis as the lowest quartile, treating men and women separately. The lowest group for SM was defined as sarcopenia. Pancreatic exocrine insufficiency (PEI) was defined as a percentage 13CO2 cumulative dose at 7 h of less than 5%.
Results: Low SM (sarcopenia) was associated with PEI in both men (P<0.001) and women (P=0.012). Serum albumin was associated with PEI in males only (P=0.005). Among all patients, sarcopenia (P=0.001) and serum albumin (P=0.058) were associated with PEI. On multivariate analysis, only sarcopenia remained independently associated with PEI (P<0.001).
Conclusions: Sarcopenia is independently associated with PEI in patients with pancreatic disease.
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