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Decrease of CC-Family Chemokines Levels in the Heart Tissue of Aged Rats Following Severe Acute Pancreatitis: A New Mechanism of Heart Protection During Systemic Inflammation
rizia c. amaral, denise f. barbeiro, Marcia K. Koike, fabiano p. silva, Marcel C. Machado*
Clinical Emergency, University of SaoPaulo, Sao Paulo, Sao Paulo, Brazil
Introduction/Background
Severe acute pancreatitis (AP) in the elderly is followed by an increased mortality and morbidity rates putting in evidence that the severity of the systemic response is more intense in this population Sustained inflammatory response in distant organs like the heart,may be implicated in this age related vulnerability CC chemokines are the largest subfamily of chemokines, which are important components of the innate immune system.
Chemokines trigger leukocyte trafficking and are implicated in cardiovascular disease pathophysiology.The aim of the present study was to investigate if the cardiac inflammatory response and chemokines expression could be more exacerbated in the elderly, during severe pancreatic injury
Methods: AP was induced in male Wistar rats by an intraductal 2.5 % taurocholate injection and divided into 2 experimental groups(20 rats each group) G-1 young (3 month old rats) and G-2 older (18 month old rats) Eleven hours after AP heart tissue was collected for evaluation of gene expression of chemokines and cytokines
Results :It was observed an increased expression of chemokines CCL-1, CCL-11 and CKCL-1 in the heart of control aged rats when compared to young animals. However we observed a decreased of chemokines expression 11 h after AP induction in old animals without changed in chemokines expression in young rats. Lower levels of I L-10 and IL-6 gene expression was also observed in the heart of old rats with AP
Conclusion These unexpected results suggest that in old rats decreased expression of heart chemokines after AP may represent a protective mechanism from further heart damage during systemic inflammatory processes such as severe pancreatic injury.
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