|
Back to 2015 Annual Meeting Program
Risk of Intestinal Malignancy in Patients With Short Bowel Syndrome
Jon S. Thompson*, Rebecca a. Weseman, David F. Mercer, Fedja a. Rochling, Luciano Vargas, Wendy Grant, Alan Langnas
University of Nebraska Medical Center, Omaha, NE
Background:
Post resection intestinal adaptation is an augmented self-renewal process which might increase the risk of malignant transformation in the intestine. Furthermore, patients with short bowel syndrome (SBS) may have other risk factors (e.g., underlying disease) and therapies which might increase this risk as well. Our aim was to determine the incidence of new intestinal malignancy in SBS patients.
Methods:
We reviewed the records of 500 adult SBS patients identified from 1982-2013. There were 199 men and 301 women ranging in age from 19 to 91 years. Follow up from the time of diagnosis of SBS ranged from 12 to 484 months. 186 (37%) patients were followed for more than 5 years.
Results:
The cause of SBS was postoperative in 35% patients, malignancy/radiation in 19% patients, mesenteric vascular disease in 17% patients, Crohn's disease in 16% patients and other in 13% patients. Twenty-eight (6%) patients received growth stimulatory medications. Fifteen percent of patients had a prior total colectomy. Twenty-eight (6%) patients underwent intestinal transplantation. One hundred fifteen (23%) patients had a previous abdominal malignancy, including colorectal cancer in 43 patients. Thirty-six (7%) received radiation therapy. Recurrent colon cancer was found in two patients, one at a stoma and the other with lung metastases. New colon cancer was found in one patient (0.2%), a 62-year-old female with long-standing Crohn's disease.
Conclusion:
The incidence of colon cancer in this heterogenous group of patients with SBS was similar to the normal population. This suggests that the risk of developing a new colon cancer in patients with the SBS is not increased.
Back to 2015 Annual Meeting Program
|
