|
|
Back to 2015 Annual Meeting Program
Is There a Relationship Between Body Composition and Blood Micronutrient Concentrations in Male and Female Patients With Operable Colorectal Cancer?
Fiona J. Conway1, Colin H. Richards1, 2, Campbell S. Roxburgh1, Paul G. Horgan*1, Donald C. Mcmillan1
1Academic Unit of Surgery, University of Glasgow, Glasgow, United Kingdom; 2Department of Surgery, NHS Grampian, Aberdeen, United Kingdom
Rationale: Blood micronutrients are commonly used to assess nutritional status. Implicit in such measurements is that they reflect overall nutritional status. However, few studies have examined the relationship between body composition and blood micronutrient measurements. The aim of the present study was to examine the relationship between body composition and blood micronutrient concentrations in patients with CRC.
Methods: Blood samples were collected pre-operatively in patients (N = 48) undergoing potentially curative resection for CRC between June 2004 and July 2009 for plasma retinol, vitamins B1, B2, B6, C, D and E, lutein, lycopene, carotenoids and zinc. Image analysis of pre-operative CT scans measured total fat index (TFI, cm2/m2), subcutaneous fat index (SFI, cm2/m2), visceral fat index (VFI, cm2/m2) and skeletal muscle index (SMI, cm2/m2). Patients were followed up until March 2014.
Results: Median concentrations of vitamins A, B1, B2, B6, D and E, lutein, carotenoids and zinc were within the laboratory reference ranges whereas vitamin C and lycopene were below reference ranges. Clinicopathological characteristics and micronutrient concentrations were similar between male and female patients. Male patients had significantly higher VFI and SMI than female patients (both p<0.01). Male patients had reduced concentrations of vitamins B1 and B2 in association with reduced SMI (both p<0.05), increased concentrations of vitamin B2, lycopene, a-carotene in association with increased BMI (all p<0.05), increased concentrations of vitamin B2 and zinc in association with increased TFI (both p<0.05), increased concentrations of β-carotene in association with increased VFI (p=0.043) and increased concentrations of zinc in association with increased SFI (p=0.021). Female patients had reduced concentrations of retinol, vitamins B2 and D in association with reduced SMI and sarcopenia (all p<0.05), increased concentrations of vitamin B2 in association with increased BMI (p=0.026) and increased vitamin C concentrations in association with TFI (p=0.024).
Conclusions: Of the micronutrients examined, only vitamin B2 was consistently directly associated with body composition, independent of sex. These results would suggest that other factors may confound the expected association between body composition and blood micronutrient concentrations. It was of interest that vitamin B2 concentrations were measured in red cells rather than plasma.
Table 1: The relationship between sex and components of body composition
| Body Composition | Male | Female | P value | Body Mass Index
(BMI, kg/m2) | 27.9 | 25.7 | 0.238 | Total Fat Index
(TFI, cm2m2) | 129.5 | 143.6 | 0.508 | Subcutaneous Fat Index
(SFI, cm2m2) | 64.3 | 104.6 | 0.072 | Visceral Fat Index
(VFI, cm2m2) | 53.2 | 39.3 | 0.008 | Skeletal Mass Index
(SMI, cm2m2) | 46.8 | 37.3 | 0.001 | Sarcopenia (No/ Yes)
Males <52.4cm2m2
Females <38.5cm2m2 | 6/ 16 | 11/ 15 | 0.283 |
Mann Whitney
Back to 2015 Annual Meeting Program
|
