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Open cytoreductive Surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) has emerged as the procedure of choice for mucinous adenocarcinoma of the appendix (MAA), however is associated with substantial morbidity. We present a case of a totally laparoscopic R0- CRS-HIPEC for MAA. CRS included: right hemicolectomy, omentectomy, cholecystectomy, bilateral salpingo-oopherectomy, excision of the round and falciform ligaments and stripping of the peritoneum of the right diaphragm; followed by HIPEC through single inflow and outflow catheters. OR time was 380 mns and EBL was 100 mL. There was no postoperative morbidity. The patient was discharged home on postoperative day 8.