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Recently, a new endoscopic method for reducing lower esophageal sphincter pressure in achalasia patients, per-oral endoscopic myotomy (POEM), has been developed. The most difficult part of POEM is the submucosal dissection, which spatially separates the mucosa and the musculature and provides an intact tissue plane for secure esophageal closure. The purpose of this video is to review six technical pearls identified over our series of POEM patients that permit successful, reproducible creation of the submucosal tunnel.