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This video shows a transanal hybrid natural orifice transluminal endoscopic surgery (NOTES) sigmoidectomy performed in a cadaver model using a TEM proctoscope. We employ a combined laparoscopic and endoscopic technique to place a stapler anvil in the proximal colon prior to initiation of colon dissection. This allows for a completely intra-corporeal anastomosis to be performed without the need for colon exteriorization. Techniques for occluding the rectal lumen with a purse-string suture, performing a full thickness dissection at the rectosigmoid junction, and creating a colorectal anastomosis through the TEM proctoscope are also shown.