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Gastrointestinal stromal tumors are rare neoplasms of uncertain malignant potential. The most common site of origin is the stomach. Approximately 5% of all GISTs originate from the esophagus. Traditional management of gastric GIST is wedge resection to grossly negative margins. Tumors located at the GE junction are difficult to resect without impairing esophageal emptying. Tumors in the esophagus cannot be resected with wedge resection techniques. Rather than performing an esophagectomy, enucleation of low-risk lesions may be appropriate. We present a video demonstrating the laparoscopic resection of two GIST lesions in difficult anatomic locations: the GE junction and the distal esophagus.