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Introduction: ICR is the most commonly performed procedure in patients with Crohn’s disease yet there are few reports regarding long term QL and factors associated with it. Patients and Methods: All patients who had ICR between 1990 and 2010 were identified from a prospectively maintained IBD database. A12 item questionnaire which included questions regarding current status, use of postoperative medications, tobacco history, need for further surgery, fertility (in females) as well as the short version of the IBDQ [scores ranging from 1 (poorest) to 7 (best)] were mailed to all patients. Uni and multivariate analyses were performed to determine factors associated with QL. Results: Of 434 patients surveyed, 206 (47.5%) (mean age 33.9+/- 12.3 years at the time of surgery; 122 women) responded. Eighty-six (41.7%) received postoperative maintenance therapy and 25 (12.1%) are current smokers. Overall, 88 (42.7%) patients reported having recurrent disease of which 71 (80.6%) were clinical recurrences and 17 (19.8%) required surgery, 15 of them resection of the previous ileocolic anastomosis. Eighteen (15%) of the 119 females who responded stated they had fertility problems (at least one episode longer than 12 months trying to get pregnant) although 17 were ultimately successful in becoming pregnant. The mean SIBQ score was 5.2 +/- 1.3 with scores ranging from 1.4 to 7.0 in the four domains. On multivariate analysis only recurrence of Crohn’s disease (p<0.001) and the absence of penetrating disease at the original surgery (p=0.039) were associated with decreased SIBD scores. Conclusions: Most patients have a good QL following ICR. However non-penetrating disease at surgery and disease recurrence appear to negatively impact on QL.