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Background:
The number of lymph nodes resected and its impact on survival for patients with esophageal cancer remains undefined. Current guidelines recommend extended lymphadenectomy in patients not receiving neoadjuvant therapy. We reviewed our single institutional experience with nodal harvest for esophageal cancer in a non-neoadjuvant therapy setting.

Methods:
Patients who underwent esophagectomy as primary therapy were indentified from a prospectively maintained database consisting of 704 patients who underwent esophagectomy. Patients were stratified by number of lymph nodes (LN) resected: >5, 10, 12, 15, or 20. Survival, clinical and pathologic parameters were analyzed with Kaplan-Meier curves, chi-square or Fisher’s exact tests where appropriate.

Results
We identified 246 patients who underwent esophagectomy as initial treatment. The mean age was 65 years ±10 years. The majority of patients were male (87%). Ivor-Lewis esophagectomy was performed for 71%, minimally-invasive esophagectomy for 15%, transhiatal esophagectomy for 12%, and three-field esophagectomy for 2%. At 60 month follow-up, there was no statistically significant difference in overall survival (OS) or disease free survival (DFS) between patients with < vs. >5 LN resected (p=0.74 and p=0.67, respectively) or in the < vs. >10 (p=0.33, p=0.11), 12 (p=0.82, p=0.90), 15 (p=0.45, p=0.79), or 20 (p=0.72, p=0.86) resected LN groups. Patients were then sub-divided into node positive and node negative cohorts and stratified by nodal harvest. In the subgroups of patients with node-negative and node-positive disease, OS and DFS also did not significantly differ between groups with respect to number of nodes resected (p>0.05). A total of 49 (20%) patients developed recurrent disease; however recurrence was not statistically associated with number of LN resected (p>0.05).

Conclusion
We found no impact of extent of lymphadenectomy on overall or disease free survival in patients treated with esophagectomy without neoadjuvant therapy. In addition, the number of nodes resected at esophagectomy did not affect recurrence rates. Current recommendations for increased nodal resection during esophagectomy in patients not receiving neoadjuvant therapy may not improve patient outcomes, and this phenomenon warrants further investigation.