BackgroundEndoscopic therapies were introduced for treatment of superficial cancer with the goal of esophageal preservation. These techniques have limitations based in sampling errors and histologic accuracy.ObjectiveTo determine feasibility of transoral endoscopic resection of the esophageal mucosal-submucosal complex (MSC) in an animal model.MethodsUsing flexible endoscopic surgery, a sleeve of MSC is resected over the entire esophageal length.Conclusion This video demonstrates proof of concept for transoral endoscopic esophagectomy. When stricture formation is controlled with extra cellular matrix substitution, this technique may be an alternative to traditional esophagectomy.