Background: Strictureplasty is well established as a safe and effective surgical therapy for Crohn’s Disease (CD). Yet, postoperative recurrence following strictureplasty remains a problem for CD patients, and associated risk factors are still uncertain. The goal of this study is to examine the relationship between recurrence and the number of both strictures (NSX) and strictureplasties (NSXP). Study Design: The authors’ prospectively-created database was used to retrospectively identify patients who had undergone strictureplasty between 1983 and 2008. Recurrence was defined as reoperation, and rates were compared based on the NSX and NSXP using Kaplan Meier curves. Cox regression analyses were used to evaluate the relationship between both NSX and NSXP and recurrence after adjusting for potential confounders.Results: A total of 339 strictureplasties were performed in 88 patients at initial operation. The five-year reoperation rate was 14% for patients with ≤8 strictures compared to 31% for those > 8 strictures (p = 0.01); and five-year reoperation rate was 14% for patients with ≤ 4 strictureplasties compared to 33% for those with > 4 strictureplasties (p<0.01). In multivariate regression of NSX and NSXP as continuous variables, both were independently associated with recurrence (p≤0.01), with an 8% increase in recurrence for each additional stricture and 22% increase in recurrence for each additional strictureplasty. Conclusions: These data suggest that both the NSX and NSXP are associated with CD recurrence and may be used as prognostic indicators for CD.