Introduction: Minimally invasive surgery has been applied in a number of ways to esophagectomy. Newer techniques have improved patient outcomes while maintaining oncological principles, however, mortality still exists. The aim of this study was to asses the feasibility of performing MIE with a combined thoracoscopic and laparoscopic approach at a NUTCC. Methods: Minimally invasive esophagectomies (MIE) in the form of combined thoracoscopic and laparoscopic esophageal resections that were performed cooperatively by two surgeons between September 2005 and August 2008 were retrospectively reviewed. The records were reviewed with respect to preoperative and postoperative data, thirty-day mortality, morbidity and histopathology data.Results: Thirty four(34) patients underwent minimally invasive esophagectomy for esophageal disorders, 61% for adenocarcinomas, 21% for squamous carcinomas, and 9% for high-grade dysplasia with Barrett’s.3 patients underwent MIE for benign conditions(2 for end stage achalasia and 1 for corrosive esophageal stricture). Mean age at presentation was 62.6 years. Comorbidities were documented in 79% of the study group, with 53% being ASA class III and 41% as ASA class IV. Most patients (68%) presented with dysphagia. A total of 18 patients (58%) had received preoperative chemoradiotherapy. The mean operating time was 294 minutes. Mean blood loss was 302 mL. The mean intraoperative transfusion rate was 21%. Three patients (9%) required extension to mini-celiotomy. The mean length of hospital stay was 14.6 days. Delayed gastric emptying was the most common complication in the postoperative period, and was seen in 15 % of patients. Three patients (9%) required a reoperation for wound problems. There was no anastomotic leak. There was no mortality reported in the series. The overall morbidity was 48%.Conclusions: Minimally invasive esophagectomy can be performed with results that meet and exceed reported benchmarks in terms of perioperative outcome at NUTCC. The combined (Thoracoscopy and Laparoscopy) technique may help to achieve low mortality and hence better safety. It is a team-based approach, as factors beyond the surgical technique affect the outcomes of surgery.