Objective: To compare the operative outcomes between different open and minimally invasive esophageal resection techniques. Methods: All patients undergoing esophageal resection were entered in to a prospectively maintained database. After approval from Institutional Review Board the database was queried to extract data on patients who underwent esophagectomy with gastric pull-up. Results: Ninety-four patients underwent esophageal resection and gastric pull-up with cervical esophago-gastric anastomosis between 2003 and 2008. Of these there were 28 open transthoracic (TTE), 39 open transhiatal (THE), and 27 minimally invasive esophagectomy (MIE). The age of patients undergoing THE was significantly higher than the TTE and MIE groups. There was no significant difference in sex or co-morbidities between the 3 groups. . 60% of THE, 64% of TTE and 74% of MIE patients underwent neoadjuvant therapy. There was significantly higher blood loss in THE (857cc) and TTE(785cc) as compared to the MIE group (430 cc) resulting in a significantly higher percentage of patients in TTE (82%) and THE (69%) requiring blood products as compared to MIE (26%) group. The operation duration were all significantly different with TTE being the longest in duration at 502.6min, followed by MIE at 429.1min, and 328.3min. There were significantly more lymph nodes removed in the TTE verse THE group (p=0.001) with 19.4 (range 39-11)and 12.9 (range 25-3) respectively. There was on average 15.6 (range 42-1) lymph nodes removed in the MIE patients which was not significantly different from either THE or TTE. Post-operatively there was one death in each the THE and MIE groups and no post-operative deaths in the TTE group. There was no significant difference in mean hospital stay between the groups, with the median stay being 13,13 and 14 days in the TTE, MIE, and THE groups. There were significantly higher complications in THE compared to TTE and MIE groups. Conclusions: There is significantly decreased blood loss and requirement for blood transfusion along with decreased morbidity with MIE compared to TTE and THE.