Feasibility Study of Same Setting Laparoscopic Bipolar Radiofrequency Ablation and Laparoscopic Colectomy for Synchronous Colorectal Liver Metastasis As a Bridge to Hepatic Resection
Cherif Boutros*, Bing Yi, Ponnandai Somasundar, N. Joseph Espat
Roger Williams Medical Center, Providence, RI
Introduction: Resection of colorectal hepatic metastasis (CHM) is the gold standard, but its timing is controversial; particularly for synchronous disease. Simultaneous resection of CHM can add time and morbidity to 1ary colorectal procedure. MONOPOLAR radiofrequency ablation (RFA) is lengthy and cumbersome. Staged hepatic resection following systemic chemotherapy has been associated with chemotherapy associated steatohepatitis (CASH). In this feasibility study, a strategy of simultaneous laporoscopic colectomy (LAP.COL), laparoscopic BIPOLAR RFA followed by 4 cycles chemotherapy prior to staged CHM resection was evaluated. Methods: Using a prospectively maintained hepatobiliary database, patients undergoing the above regimen were identified. Duration of LAP.COL-RFA procedure, RFA-procedure added time, liver treatment associated morbidity (LTAM) and treatment interval disease progression (TIDP) were assessed. Pathological evaluation of the resected liver specimens was reviewed for viable tumor in previously ablated areas and CASH. Results: Eight synchronous CHM were ablated at same setting LAP.COL in five high risk patients [age >65, ASA 3, rectal cancer (n=4)]. Mean RFA time/ lesion was 7min.±3. Thus far, 3/8 patients have completed treatment algorithm inclusive of staged CHM resection without evidence of TIDP. There was no LTAM identified after ablation (n=5) or after staged resection (n=3). Pathologically, no evidence of CASH was identified in the resected specimens, and there was NO active tumor in previously ablated areas.Conclusion: This feasibility study supports the above strategy as a bridge to resection in high risk patients; with minimal impact on the length of procedure and without TIDP or LTAM. These observations support proceeding to a formal study with the intent to evaluate impact of diminished/abolished hepatic tumor load treated by initial ablation on the duration of subsequent systemic therapy, the potential impact on the duration of post-resection chemotherapy and evaluating post therapy sustained response.
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