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2007 Program and Abstracts | 2007 Posters
Detection of Significant Prognostic Factors Using Gene-Expression Profiling in Patients with Esophageal Squamous Cell Carcinoma Yoshio Ishibashi*, Hideyuki Kashiwagi, Yutaka Suzuki Suzuki, Nobuo Omura, Koji Nakada, Katsutoshi Kobayashi, Naruo Kawasaki, Kazuto Tsuboi, Akira Matsumoto, Mitsuyoshi Urashima, Katsuhiko Yanaga Surgery, Jikei University Shool of Medicine, Tokyo, Japan
Background: To screen key molecules to aid the prediction of prognosis of patients with esophageal cancer, we have previously reported gene-expression profiling in esophageal cancer. The expressions of a variety of genes related to cell cycle, gene-repair, tumor invasion, apoptosis and chemoradiotherapy resistance were up-regulated in the poor prognostic cluster. In the current study, the protein expression patterns of these genes within esophageal cancer cells were examined immunohistochemically to determine their relation to clinicopathologic findings and disease recurrence-free survival of patients.
2007 Program and Abstracts | 2007 Posters |
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