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2007 Program and Abstracts | 2007 Posters
High Ubch10 Protein Expression As a Marker of Poor Prognosis in Esophageal Squamous - Cell Carcinoma
Akira Matsumoto*1, Yoshio Ishibashi1, Mitsuyoshi Urashima2, Katsutoshi Kobayashi1, Nobuo Omura1, Kazuto Tuboi1, Naruo Kawasaki1, Yutaka Suzuki1, Koji Nakada1, Hideyuki Kashiwagi1, Katsuhiko Yanaga1
1Department of Surgery, JIkei University School of Medicine, Minato-ku,Tokyo, Japan; 2Divisions of Clinical Research, JIkei University School of Medicine, Minato-ku,Tokyo, Japan

Purpose: To screen key molecules to aid the prediction of prognosis in esophageal cancer, we previously carried out and reported gene-expression profiling: we found that RNA expressions of ubiquitin-conjugating enzymes were regulated in patients with a poor outcome. Therefore, we focused on ubiquitin-conjugating enzyme H10 (UbcH10) which is indispensable in the cell-cycle transition from metaphase to anaphase, and investigated whether this protein expression levels of UbcH10 in cancerous esophageal lesions affected the prognosis of patients with esophageal squamous - cell carcinoma by evaluating more patients for a longer piriod. Experimental Design:Paraffin - embedded tissue samples from 121 patients with esophageal squamous - cell carcinoma were stained with anti-UbcH10 antibody for immunohistochemical analysis.
Results: UbcH10 was expressed in cancerous and dysplastic lesions, but not in normal tissue. Depending on the staining pattern, patients were grouped according to expression: high (N=33) or low (N=88).There were significant differences between the groups in terms of invasion into lymphatic vessels, number of metastatic lymph nodes,TNM classification, and stages as well as survival: the 50% survival rate in the high expression group was 2.3 years, as compared with 9.9 years for the low expression group (P < 0.0001). Even with multi-variate adjusting for stage 0 to stage IV using the Cox proportional hazard model, patients belonging to the high-expression group had a poorer prognosis (HR: 2.5; 95% CI: 1.3 - 4.5; P = 0.004).
Conclusions: High UbcH10 protein expression Sseems to be a novel marker of poor prognosis in esophageal squamous - cell carcinoma.

2007 Program and Abstracts | 2007 Posters
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