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Back to 2007 Program and Abstracts
A Neurokinin 1 Receptor Antagonist (NK-1ra) Decreases Adhesion Reformation After Laparoscopic Lysis of Adhesions (Loa) in a Rat Model Scott G. Prushik*1, Cary B. Aarons1, Ronald Matteotti1, Karen L. Reed1, ADAM C. Gower1, Arthur F. Stucchi1, Susan E. Leeman2, James M. Becker1 1Surgery, Boston University, Boston, MA; 2Pharmacology, Boston University, Boston, MA
Introduction: Up to 94% of patients develop fibrous adhesions following abdominal surgery and a significant number of these patients will require a second operation for LOA. We have previously shown that inhibition of binding of the proinflammatory peptide, substance P, to its receptor using the NK-1RA CJ-12,255 (Pfizer) decreased primary adhesion formation and upregulated the peritoneal fibrinolytic system in a rat model. While most studies have focused on the prevention of primary adhesions, few have addressed adhesion reformation following LOA. The aim of this study was to determine the effects of NK-1RA administration on adhesion reformation and peritoneal fibrinolytic activity following LOA.
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