2005 Abstracts: Microwave Ablation with Dual Loop Probes:Results of a Phase I Clinical Trial
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Microwave Ablation with Dual Loop Probes:Results of a Phase I Clinical Trial
Kenneth Meredith, fred lee, david m. mahvi, univ of wisconsin, madison, WI
INTRODUCTION: A number of options are available to patients with hepatic tumors not amendable to a curative resection. Local ablative techniques have expanded the patient population amenable to treatment, but local recurrence rates after the most common ablative technique (radiofrequency ablation) remain high particularly adjacent to blood vessels. Microwave ablation results in a larger area of active heating and may offer some theoretical advantages compared to RFA.
METHODS:We developed a dual loop probe apparatus which consists of two 13-gauge needles through which 24-gauge loop antennas (2.7 cm in diameter) are deployed. The loops are canted at 45 degrees. This orientation resulted in the most consistent lesions in prior animal models. We evaluated the ability of this device to ablate tumor inside the loop. RESULTS: Five patients underwent 6 ablations followed by resection of the ablated liver. There was no toxicity related to the device. All tumor and normal tissue within the loop was ablated. Ablation volume was 28.2 + 8.4 cm3. Tumor adjacent to blood vessels within the loop was dead. No distortion of the microwave lesion was created by proximity to blood vessels. CONCLUSIONS: Microwave ablation by the dual loop probe system is a safe alternative for patients with hepatic tumors who are not candidates for a curative resection. Ablation with the system resulted in complete tumor kill at the ablation/tumor interface as well as adjacent to surrounding blood vessels. The advantages of this configuration includes its ability to completely encircle a tumor, and deliver large amounts of precisely targeted microwave energy to the tumor with minimal damage to tissue outside the loop.
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