2005 Abstracts: Multiple Cool Tip Radiofrequency Ablation Probes and a Switching Controller Compared to Standard Clustered Radiofrequency Probes in the Porcine Model
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Multiple Cool Tip Radiofrequency Ablation Probes and a Switching Controller Compared to Standard Clustered Radiofrequency Probes in the Porcine Model
David A. Iannitti, Dionisios Vrochides, Jason McKee, Damian E. Dupuy, Brown Medical School, Providence, RI
PURPOSE: Evaluation of the Switching Controller with multiple, combined cool tip probes for an output-based radiofrequency device.
METHODS: Radiofrequency (RF) ablation was performed in three randomly selected segments of the liver in 12 pigs. Half of the ablations were performed with a Pringle maneuver and half without. Ablations were performed with three 3.0 cm active tip, cooled RF probes spaced 2.0 cm. apart and a 200 watt RF generator. Ablations using the standard cluster of probes were performed for 12 minutes in the non-Pringle subgroup and 6 minutes in the Pringle subgroup. Ablations using the Switching Controller with multiple, combined cool tip probes were performed for 16 minutes in the non-Pringle subgroup and 8 minutes in the Pringle subgroup. The Switching Controller delivered current that alternated among the probes, based on impedance (to 30 Ohms above baseline) and time (up to 30''). The ablation dimensions, volume, temperature, current delivery parameters and histology were evaluated. RESULTS: A total of 34 ablations were performed. The minimum ablation diameter (Dmin) in the standard cluster group was 40.3 ± 4.3 mm (42.5 ± 4.1 mm for the Pringle group and 38.1 ± 3.6 mm for the non-Pringle group). The maximum ablation surface area (SAmax) in this group was 16.0 ± 3.3 cm2 (17.6 ± 2.2 sqcm for the Pringle group and 14.2 ± 3.5 cm2 for the non-Pringle group). The ablation volume in the cluster group was 36.9 ± 9.5 cc (40.1 ± 8.1 cc for the Pringle group and 33.7 ± 10.4 cc for the non-Pringle group). In the Switching Controller Multiprobe group, the ablation Dmin was 51.4 ± 7.4 mm (54.5 ± 8.5 mm for the Pringle group and 48.2 ± 4.8 mm for the non-Pringle group). The ablation SAmax in this group was 22.4 ± 4.7 cm2 (23.9 ± 4.9 cm2 for the Pringle group and 20.8 ± 4.1 cm2 for the non-Pringle group). The ablation volume in the multiprobe group was 66.1 ± 17.9 cc (68 ± 16.8 cc for the Pringle group and 64.3 ± 19.6 cc for the non-Pringle group). CONCLUSIONS: Technology to increase the size of ablated areas and shorten the procedural time evolves. The use of the Switching Controller resulted in ablation of lesions with larger Dmin , SAmax and volume than with the standard cool tip cluster. The Pringle maneuver lead to the creation of an equally sized lesion in half of the time.| Dmin(mm) | SAmax(cm2) | Vol(cc) | |
| Cluster | 40.3 | 16.0 | 36.9 |
| Multi | 51.4 | 22.4 | 66.1 |
| p value | < 0.0001 | 0.0002 | < 0.0001 |
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