Background & Aim: The appropriate operation to treat reflux disease associated to Barrett's esophagus (BE) remains controversial. This paper compares the long-term results of Nissen and Collis-Nissen operations when treating this condition. Methods: Thirty-three patients underwent a standard Nissen fundoplication (Nissen) and 51 patients had a Collis-Nissen repair (CollisN) over a 25-year period. Symptoms, esophagogram, radionuclide emptying, manometry, 24-hour pH study, and endoscopy were assessed pre- and postoperatively. Operative failure was defined as either an abnormal fundoplication or mucosal damage, with or without reflux symptoms. Results: There were no operative deaths in either group. Evaluation of results at 8.3 years follow-up is summarized as follows: