Abstracts
2002 Digestive Disease Week

# 100087 Abstract ID: 100087 Prognostic Factors after Hepatic Resection for Hepatocellular Carcinoma with Hepatitis B Viral Infection: Univariate and Multivariate Analysis
Miin-Fu Chen, Tai Pei, Taiwan

Objective. To study the clinicopathologic factors influenced the long-term outcome of heaptitis B virus (HBV)-related hepatocellular carcinoma (HCC) after hepatectomy. Summary background data. In Taiwan the HBV infection is high, the carrier rate of heaptitis B surface antigen (HBsAg) was 15% in the general population. Most patients with HCC was considered to be related to HBV. Little has been established regarding the prognostic factors after resection of HBV-related HCC. Methods. The surgical outcomes of HBV-related HCC in 289 patients who underwent hepatic resection between 1986 and 1998 were retrospectively clarified. Postresection prognostic factors were calculated by univariate and multivariate analysis using Cox's proportional hazards model. Results. The overall incidence of postoperative complications was 14.2% and surgical mortality rate was 5.2%. The 1-, 3-, and 5-year disease-free survival rates were 50.9%, 33.98% and 27.03%, respectively. The overall cumulative survival rates at 1,3 and 5 year were 63.14%, 41.88% and 31.83%, respectively. The use of Cox's multivariate proportional hazards model indicated that significant prognostic indicators were alpha-fetoprotein, alkaline phosphatase, blood transfusion, multiple tumors, portal vein invasion and resection margin. Conclusions. We found the postresection survival of patients with HBV-related HCC should be stratified by the high value of alpha-fetoprotein and alkaline phosphatase, multiple tumors, portal vein invasion, perioperative blood transfusion, and inadequate resection margin.