Abstracts
2000 Digestive Disease Week

# 2276 Surgical Results in Patients with Hepatitis Virus Related Hepatocellular Carcinoma in Taiwan.
Miin-Fu Chen, Wei-Chen Lee, Long-Bin Jeng, Taipei, Taiwan, ROC

To evaluate the surgical results in patients with hepatitis virus related hepatocellular carcinoma (HCC), 252 patients, 196 male and 56 female, who had undergone hepatic resection for HCC from March, 1992, to August, 1998, with complete profiles of hepatis virus markers study were reviewed. The patients were divided into 4 groups, 30 patients (11.9%) without neither hepatitis B surface antigen (HBsAg) or anti-hepatitis C antibody (Anti- HCV Ab) (N-HCC group), 133 patients (52.8%) with positivity of HBsAg only (B-HCC group), 66 patients (26.2%) with positivity of Anti-HCV Ab only (C-HCC group), and 23 patients (9.1%) with positivity of either HBsAg and anti-HCV Ab (BC-HCC group). Compared to the patients in other groups, the patients in C-HCC group were older and were associated with more severe cirrhotic change of the liver. The surgical complication rates and hospital mortalities in C-HCC and BC-HCC groups were 30.3%, 12.1% and 30.4%, 17.4%, respectively, which were higher than those of N-HCC (13.3%, 3.3%) and B-HCC (15.8%, 3.8%) groups. The mean disease-free survival for N-HCC, B-HCC, C-HCC and BC-HCC groups were 31.4 months, 25.4 months, 38.9 months and 13.8 months, respectively. The difference between these four groups was statistically significant (p < 0.05). However, the mean overall survival time, 38.3 months for N-HCC group, 37.2 months for B-HCC group, 52.1 months for C-HCC group, and 32.7 months for BCHCC group, were not different statistically (p=0.146). In conclusion, the surgical treatment for HCC related to hepatitis C or dual hepatitis B and C were associated with higher surgical complication rate and hospital mortalities. Hepatocellular carcinoma-related to dual hepatitis B and C infection recurred earlier after hepatectomies. But, the overall survival between these four groups was not different statistically.